Dr. Malte Gersch’s research study focuses on biochemical procedures in intracellular communication, where the protein ubiquitin marks other proteins to manage their degradation, transport or activity– rather like a “molecular Post-it”. In the brand-new UbiPRO project, he will study the catalytic activities of special enzymes called deubiquitinases (DUBs). For this function, Gersch will establish a chemoproteomic platform for evaluating the activity of these enzymes. With the aid of unique, chemically modified ubiquitin probes, he will duplicate intricate polyubiquitin structures and decipher the mechanisms by which DUBs acknowledge and process specific signals. The task integrates methods from protein chemistry, chemoproteomics and structural biology, and aims to gain new insights into the regulation of the ubiquitin system– potentially leading to a better understanding of illness mechanisms and the advancement of restorative methods.
About Dr. Malte Gersch
Dr. Malte Gersch studied chemistry and biochemistry at LMU Munich. A research study remain at Stanford University School of Medicine awakened his interest in chemical biology, and he consequently completed his postgraduate degree under the supervision of Professor Stephan Sieber at the Technical University of Munich, where he conducted research on the function and inhibition of the bacterial proteasome ClpP. Throughout his postdoctoral remain at Professor David Komander’s lab in Cambridge, UK, he concentrated on the regulation and structure of human deubiquitinases. He transferred to Dortmund at the end of 2018, where he heads an Emmy Noether independent junior research group at the Department of Chemistry and Chemical Biology of TU Dortmund University and works at the Chemical Genomics Center (CGC) at limit Planck Institute for Molecular Physiology. Dr. Malte Gersch has actually gotten many awards for his research study, including the Hans Fischer Prize, the Friedrich Weygand Prize, the Emil Erlenmeyer Medal and the ORCHEM Reward.
About the ERC Consolidator Grant
With the ERC Consolidator Grant, the European Research Council supports outstanding researchers who have developed an exceptional scientific profile within twelve years of completing their doctoral degree. This specific funding provides grant holders the chance to carry out especially innovative and pioneering work in the natural sciences.
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